|
KMID : 1123920040180061860
|
|
Korean Journal of Oriental Physiology and Pathology
2004 Volume.18 No. 6 p.1860 ~ p.1868
|
|
|
Influence of Geijibokryunghwan on Platelet Aggregation, Cyclic AMP, Cyclic GMP, TXA2, Ca2+ Mobilization, Tyrosine Phosphorylation of PLC-2 and IP3 in Activated Platelets
|
|
Kim Han-Geu
Moon Jin-Young
Park Sun-Dong
Choi Dall-Yeong
Kim Cherl-Ho
Park Won-Hwan
Kim Jong-Gu
Kim Seog-Ha
Sa Eun-Ho
Kim Jae-Woo
|
|
|
Abstract
|
|
|
|
Geijibokryunghwan has a wide range of therapeutic applications, and some reports have indicated that it has protective activity against atherosclerosis, and more specifically stroke and myocardial infarction. A recent report showed that atherosclerotic plaque volume can be reduced by supplying Geijibokryunghwan extracts for several years. In this study, we used a component of Geijibokryunghwan, which has been used for the prevention of atherosclerosis in Korea for several years, and has proven to be useful in lowering the occurrence of cerebral infarction. In a preliminary study, we found that Geijibokryunghwan potently suppressed platelet aggregation induced by various agonists. In this study, we sought to explore the mechanism by which Geijibokryunghwan inhibits platelet aggregations.
|
|
|
KEYWORD
|
|
|
Geijibokryunghwan, atherosclerosis, activity, platelet, aggregations, Ca/sup 2+/ mobilization
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|